Hye Gwang Jeong Selected Research

kahweol

3/2019	Suppression of PMA-induced human fibrosarcoma HT-1080 invasion and metastasis by kahweol via inhibiting Akt/JNK1/2/p38 MAPK signal pathway and NF-κB dependent transcriptional activities.
11/2018	Kahweol inhibits proliferation and induces apoptosis by suppressing fatty acid synthase in HER2-overexpressing cancer cells.
5/2009	Kahweol blocks STAT3 phosphorylation and induces apoptosis in human lung adenocarcinoma A549 cells.
7/2008	The coffee diterpene kahweol induces heme oxygenase-1 via the PI3K and p38/Nrf2 pathway to protect human dopaminergic neurons from 6-hydroxydopamine-derived oxidative stress.
12/2006	The coffee diterpene kahweol inhibits tumor necrosis factor-alpha-induced expression of cell adhesion molecules in human endothelial cells.
1/2006	Inhibitory effect of the coffee diterpene kahweol on carrageenan-induced inflammation in rats.

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Hye Gwang Jeong Research Topics

Disease

42	Neoplasms (Cancer) 01/2022 - 02/2002
25	Inflammation (Inflammations) 10/2021 - 07/2004
16	Breast Neoplasms (Breast Cancer) 01/2022 - 07/2006
10	Carcinogenesis 12/2021 - 07/2004
8	Atopic Dermatitis (Atopic Eczema) 02/2021 - 09/2011
8	Hepatocellular Carcinoma (Hepatoma) 03/2012 - 11/2002
7	Neoplasm Metastasis (Metastasis) 03/2019 - 11/2006
6	Obesity 02/2021 - 10/2009
6	Fibrosis (Cirrhosis) 01/2020 - 12/2004
6	Fibrosarcoma 03/2019 - 07/2010
4	Body Weight (Weight, Body) 01/2022 - 12/2011
4	Hypoxia (Hypoxemia) 01/2022 - 05/2008
4	Cardiovascular Diseases (Cardiovascular Disease) 12/2020 - 11/2011
4	Atherosclerosis 11/2019 - 01/2006
4	Necrosis 03/2009 - 12/2004
3	Asthma (Bronchial Asthma) 10/2020 - 06/2009
3	Liver Cirrhosis (Hepatic Cirrhosis) 01/2017 - 11/2010
3	Dermatitis 07/2014 - 03/2013
3	Edema (Dropsy) 01/2013 - 01/2006
2	Insulin Resistance 02/2021 - 12/2013
2	Hypertension (High Blood Pressure) 01/2021 - 03/2014
2	Metabolic Diseases (Metabolic Disease) 12/2020 - 03/2013
2	Airway Remodeling 10/2020 - 06/2009
2	Lung Neoplasms (Lung Cancer) 01/2020 - 03/2015
2	Osteoporosis 01/2019 - 01/2017
2	Alcoholic Fatty Liver 08/2018 - 02/2017
2	Chronic Obstructive Pulmonary Disease (COPD) 02/2017 - 09/2011

Drug/Important Bio-Agent (IBA)

14	SaponinsIBA 11/2019 - 02/2002
10	Proteins (Proteins, Gene)FDA Link 01/2020 - 08/2008
9	CytokinesIBA 01/2022 - 01/2006
9	AntioxidantsIBA 01/2021 - 08/2008
8	Cytochrome P-450 CYP1A1 (CYP1A1)IBA 09/2015 - 11/2002
8	ChangkilIBA 02/2015 - 01/2006
7	Matrix Metalloproteinase 9 (Gelatinase B)IBA 01/2019 - 02/2010
7	Pharmaceutical PreparationsIBA 09/2017 - 09/2008
6	kahweolIBA 03/2019 - 01/2006
6	Immunoglobulin E (IgE)IBA 07/2014 - 06/2009
5	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 01/2022 - 07/2006
5	EnzymesIBA 01/2021 - 04/2008
5	Messenger RNA (mRNA)IBA 08/2017 - 03/2013
5	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 08/2017 - 07/2004
5	NF-kappa B (NF-kB)IBA 07/2010 - 09/2008
4	TriterpenesIBA 02/2021 - 02/2002
4	OvalbuminIBA 10/2020 - 06/2009
4	p38 Mitogen-Activated Protein KinasesIBA 03/2019 - 07/2010
4	Dimethylnitrosamine (Nitrosodimethylamine)IBA 01/2017 - 11/2010
4	Dinitrochlorobenzene (DNCB)IBA 07/2014 - 05/2012
4	Biological ProductsIBA 07/2014 - 05/2011
3	Small Interfering RNA (siRNA)IBA 01/2022 - 08/2004
3	Estrogens (Estrogen)FDA Link 01/2022 - 01/2017
3	o,p'-DDTIBA 10/2021 - 11/2002
3	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 02/2021 - 01/2017
3	LipidsIBA 02/2021 - 12/2011
3	Triglycerides (Triacylglycerol)IBA 02/2021 - 11/2009
3	Ethanol (Ethyl Alcohol)IBA 04/2020 - 03/2009
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 11/2019 - 09/2004
3	Epidermal Growth Factor (EGF)IBA 11/2018 - 03/2008
3	Oxidoreductases (Dehydrogenase)IBA 08/2018 - 12/2013
3	Aromatase (CYP19)IBA 08/2017 - 03/2008
3	Capsaicin (Zostrix)FDA Link 01/2017 - 04/2011
3	ElementsIBA 09/2015 - 07/2010
3	Polychlorinated Dibenzodioxins (TCDD)IBA 10/2014 - 11/2002
3	Metformin (Glucophage)FDA LinkGeneric 10/2014 - 09/2013
3	Interleukin-4 (Interleukin 4)IBA 07/2014 - 03/2013
3	Heme Oxygenase-1IBA 07/2014 - 01/2009
3	Interleukin-13IBA 07/2014 - 03/2013
3	Interleukin-5 (Interleukin 5)IBA 07/2014 - 03/2013
3	Aspartate Aminotransferases (Aspartate Transaminase)IBA 06/2013 - 12/2004
3	CarrageenanIBA 01/2013 - 01/2006
3	Anthocyanins (Anthocyanin)IBA 12/2011 - 11/2010
3	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 04/2011 - 02/2010
3	Metallothionein 3IBA 12/2009 - 05/2008
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2022 - 12/2004
2	Estrogen ReceptorsIBA 01/2022 - 08/2008
2	4- (N- methyl- N- nitrosamino)- 1- (3- pyridyl)- 1- butanoneIBA 12/2021 - 08/2006
2	SmokeIBA 12/2021 - 02/2017
2	MucinsIBA 10/2021 - 09/2011
2	3,11-dihydroxylup-20(29)-en-28-oic acidIBA 02/2021 - 01/2021
2	Glucose (Dextrose)FDA LinkGeneric 02/2021 - 12/2013
2	Fatty Acids (Saturated Fatty Acids)IBA 02/2021 - 01/2020
2	Insulin (Novolin)FDA Link 02/2021 - 12/2013
2	LipopolysaccharidesIBA 01/2021 - 01/2013
2	rutecarpineIBA 01/2021 - 12/2009
2	Betulinic AcidIBA 12/2020 - 02/2016
2	ChemokinesIBA 10/2020 - 09/2011
2	Plant ExtractsIBA 04/2020 - 01/2017
2	AllergensIBA 04/2020 - 02/2015
2	polyhexamethyleneguanidineIBA 01/2020 - 12/2019
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2020 - 09/2008
2	Carnitine O-Palmitoyltransferase (Carnitine Palmitoyltransferase II)IBA 01/2020 - 08/2018
2	XenobioticsIBA 11/2019 - 10/2014
2	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 11/2019 - 02/2016
2	platycodin DIBA 01/2019 - 01/2017
2	Fatty Acid Synthases (Fatty Acid Synthase)IBA 11/2018 - 05/2013
2	LeptinIBA 08/2017 - 05/2014
2	PPAR gammaIBA 01/2017 - 04/2008
2	Phosphotransferases (Kinase)IBA 05/2016 - 09/2008

Therapy/Procedure

6	Therapeutics 01/2022 - 09/2008
5	Traditional Medicine (Folk Remedies) 01/2021 - 01/2009
2	Oral Administration 10/2020 - 02/2010